Voxamin XR Fluvoxamine Maleate Pirfenidone
ModeratePirfenidone and fluvoxamine can interact. Fluvoxamine is a strong inhibitor of the enzyme CYP1A2, and this raises the amount of pirfenidone in the body. That can also change which side effects you are likely to get from pirfenidone. If you take fluvoxamine, your doctor may want you to stop it before starting pirfenidone, or lower the pirfenidone dose to 267 mg three times a day.
These medicines are often taken together with some care. Your doctor may change a dose, space them apart or check on you more often. Make sure your doctor and pharmacist know you take both.