Sizaject Fosphenytoin Sodium Fluoxetine
ModerateFluoxetine is on the list of medicines that can raise the level of phenytoin in the blood. Fosphenytoin turns into phenytoin in the body, so taking the two together can push the phenytoin level higher than intended. The same leaflet lists many other medicines that can do this. They include acute alcohol intake, amiodarone, chloramphenicol, chlordiazepoxide, cimetidine, diazepam, dicumarol, disulfiram, estrogens, ethosuximide, H2-antagonists, halothane, isoniazid, methylphenidate, phenothiazines, phenylbutazone, salicylates, succinimides, sulfonamides, tolbutamide and trazodone.
These medicines are often taken together with some care. Your doctor may change a dose, space them apart or check on you more often. Make sure your doctor and pharmacist know you take both.