Tepadina Thiotepa Clarithromycin
ModerateTaking clarithromycin, which acts as a CYP3A4 inhibitor, with thiotepa may increase the plasma concentrations of thiotepa and potentially decrease the concentrations of the active metabolite TEPA, much like inhibitors of CYP2B6.
These medicines are often taken together with some care. Your doctor may change a dose, space them apart or check on you more often. Make sure your doctor and pharmacist know you take both.