Rupahist Rupatadine Fumarate Itraconazole
MajorStrong CYP3A4 inhibition raises rupatadine exposure, with possible QT prolongation and sedation.
These medicines can affect each other in a serious way. Do not start taking them together unless your doctor has said it is OK. If you already take both, do not stop either one on your own: speak to your doctor or pharmacist soon.
Clinical management: Avoid or use with caution; consider an alternative antihistamine.