Apixan Apixaban Mefenamic Acid
MajorIncreased risk of major bleeding when NSAIDs are combined with direct oral anticoagulants.
These medicines can affect each other in a serious way. Do not start taking them together unless your doctor has said it is OK. If you already take both, do not stop either one on your own: speak to your doctor or pharmacist soon.
Clinical management: Avoid if possible; use gastroprotection and monitor for bleeding.