Apixan Apixaban Carbamazepine
MajorCarbamazepine, a strong CYP3A4/P-gp inducer, reduces apixaban levels and may cause stroke or thrombosis.
These medicines can affect each other in a serious way. Do not start taking them together unless your doctor has said it is OK. If you already take both, do not stop either one on your own: speak to your doctor or pharmacist soon.
Clinical management: Avoid combination. Use an alternative anticoagulant or anticonvulsant.