Halaven Eribulin Mesylate Rifampicin
ModerateIn patients with advanced solid tumours, eribulin's exposure (AUC) did not differ in any way that matters clinically when it was given with or without rifampicin. The same was true when it was given with or without ketoconazole. Rifampicin speeds up the CYP3A4 enzyme, and ketoconazole blocks it, so both were tested on purpose.
These medicines are often taken together with some care. Your doctor may change a dose, space them apart or check on you more often. Make sure your doctor and pharmacist know you take both.