Taking P-gp inhibitors with this tablet raises the AUC and Cmax of relugolix, so the risk of side effects from this tablet may go up. Taking it with medicines that are both P-gp and strong CYP3A inducers lowers the AUC and Cmax of relugolix, estradiol and/or norethindrone, so this tablet may not work as well.
These medicines are often taken together with some care. Your doctor may change a dose, space them apart or check on you more often. Make sure your doctor and pharmacist know you take both.