R-Penem Meropenem Trihydrate Valproic Acid
MajorMeropenem rapidly lowers valproate levels by 60-100%, leading to breakthrough seizures.
These medicines can affect each other in a serious way. Do not start taking them together unless your doctor has said it is OK. If you already take both, do not stop either one on your own: speak to your doctor or pharmacist soon.
Clinical management: Avoid combination; use an alternative antibiotic or another antiepileptic.