Thiotepa (Tepadina) mildly slows down an enzyme in the liver called CYP2B6, which helps break down bupropion. If you take the two together, bupropion may stay in your body longer, and the amount in your blood may go higher than usual. Tell your doctor or pharmacist if you use both, so they can watch for extra side effects from bupropion.
These medicines are often taken together with some care. Your doctor may change a dose, space them apart or check on you more often. Make sure your doctor and pharmacist know you take both.