Fesotrex ER Fesoterodine Fumarate Rifampicin
ModerateRifampicin (rifampin) and carbamazepine are CYP3A4 inducers, meaning they speed up the enzyme that breaks down fesoterodine's active form. When rifampin 600 mg was taken once a day with Toviaz (fesoterodine) 8 mg, the peak level (Cmax) of the active metabolite fell by about 70%. The total amount of it in the blood over time (AUC) fell by about 75%. Even so, the leaflet says no dose change is recommended when a CYP3A4 inducer like rifampin is used.
These medicines are often taken together with some care. Your doctor may change a dose, space them apart or check on you more often. Make sure your doctor and pharmacist know you take both.