Vasopressin

In the kidneys, vasopressin acts on the V2 receptors on the cells of the collecting ducts. When it binds there, it prompts aquaporin water channels to be inserted into the cell membranes, and this increases the amount of water taken back into the bloodstream. Urine output falls as a result, and the body's water balance stays steady. This action is useful in conditions such as diabetes insipidus, where water retention is impaired. Pharmacokinetics: the onset of action is 1 to 2 min and the half-life is 20 to 30 minutes. Vasopressin is mostly metabolized, and only about 6% of the dose is excreted unchanged in the urine. Vasopressin injection is a synthetic form of the natural antidiuretic hormone vasopressin. Its main work is to regulate the body's water balance by controlling water reabsorption in the kidneys, and it also acts as a vasoconstrictor, which helps regulate blood pressure. The medicine is used in several medical situations, including diabetes insipidus, shock states and certain bleeding disorders. Vasopressin Injection USP is usually available as a clear, colorless solution for intravenous (IV), intramuscular (IM) or subcutaneous (SC) injection.