Indications
Metastatic Colorectal Cancer Trifluridine + Tipiracil tablet is used for adults with metastatic colorectal cancer who have already been treated with chemotherapy based on fluoropyrimidine, oxaliplatin and irinotecan, and with an anti-VEGF biological therapy. If the cancer is RAS wild-type, they should also have had an anti-EGFR therapy. Metastatic Gastric Cancer The tablet is also used for adults with metastatic gastric or gastroesophageal junction adenocarcinoma who have had at least two prior lines of chemotherapy. These must have included a fluoropyrimidine, a platinum, and either a taxane or irinotecan, and, if appropriate, HER2/neu-targeted therapy.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Trifluridine and Tipiracil is a combination of two parts: Trifluridine, a thymidine-based nucleoside analog, and tipiracil, an inhibitor of thymidine phosphorylase. They are present at a molar ratio of 1:0.5 (weight ratio, 1:0.471). Tipiracil is there to raise Trifluridine exposure, because it blocks the breakdown of Trifluridine by thymidine phosphorylase.
Once Trifluridine is taken up into cancer cells, it is built into DNA. This interferes with DNA synthesis and stops the cells from multiplying. In mice, Trifluridine/Tipiracil showed anti-tumor activity against human colorectal cancer xenografts, both KRAS wild-type and mutant.
Pregnancy & Breastfeeding
Pregnancy: Trifluridine and Tipiracil can cause harm to the unborn baby, based on animal data and on how the medicine works.
Lactation: There are no data on whether Trifluridine, Tipiracil or its metabolites pass into human milk. There are also no data on their effects on a breastfed child or on milk production.
Pregnancy Testing: Check the pregnancy status of females who could become pregnant before starting Trifluridine and Tipiracil.
Contraception: Trifluridine and Tipiracil can cause harm to the unborn baby when given to a pregnant woman.
Females: Females who could become pregnant should be advised to use effective contraception during treatment with Trifluridine and Tipiracil and for at least 6 months after the final dose.
Males: Because of the potential for genotoxicity, males whose female partners could become pregnant should be advised to use condoms during treatment with Trifluridine and Tipiracil and for at least 3 months after the final dose.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.
Side Effects & Interactions
Side Effects
No side-effect data recorded yet.