Sodium Polystyrene Sulfonate

Adults: Adults (including the elderly): The average daily oral dose of Sodium Polystyrene Sulfonate for an adult is 15 gm to 60 gm, which is 1 sachet taken 1 to 4 times daily. If a patient can't take the medicine by mouth, it can be given rectally as an enema. The rectal dose is 30 gm to 50 gm of resin once or twice daily, at intervals of 6 hours. Each dose is given as a warm emulsion (at body temperature) in 150 ml to 200 ml of aqueous vehicle, such as plain water, 10% dextrose in water, or equal parts of water and 2% Methylcellulose suspension. The emulsion should be agitated gently while it is being given. The enema should be retained for as long as possible, and a cleansing enema should follow it. Children: By mouth, smaller children and infants should get correspondingly lower doses. In acute hyperkalemia, a suitable initial dose is 1 gm/kg body weight daily in divided doses. For maintenance therapy, the dose may be reduced to 0.5 gm/kg body weight daily. If the child refuses it by mouth, the resin may be given rectally, using a dose at least as much as the oral dose would have been. The resin should be suspended in a proportional amount of 10% Dextrose in water. Once the enema has been retained, the colon should be irrigated so the resin is removed properly. Neonates: The oral route is not advised for neonates, so only rectal administration should be considered. Use the minimum effective dose within the range of 0.5 to 1 gm/kg of resin. The suspension that results should be diluted as it is for adults. After the resin has been given, the colon should be irrigated well so the resin is recovered.