Informational only — Not medical advice. Always consult a licensed healthcare provider.

Community data Updated 23 hours ago

Indications

Saccharomyces Boulardii is used for the prevention and treatment of several conditions. These are diarrhea associated with antibiotics, traveler's diarrhea, recurring intestinal disease caused by Clostridium difficile, and the side effects of treatment for Helicobacter pylori. It is also used for the symptoms of acute diarrhea, diarrhea in infants, Crohn's disease, ulcerative colitis and IBS.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Saccharomyces boulardii survives stomach acid and settles in the intestinal tract, where it acts as a temporary flora and protects the beneficial organisms of the intestine. It also works with the body to re-establish the microflora, and this helps maintain and support healthy immunity, digestion and gut health. It shows the following actions. Anti-toxin activity: S. boulardii produces proteins that work to neutralize bacterial toxins, and this may include the toxins produced by Clostridium difficile. Anti-microbial: S. boulardii sticks to pathogens, so they attach less to the intestinal wall and invade enterocytes less. The pathogens are then removed during bowel movements. Enzymatic activity: in healthy adults, S. boulardii increases the enzymatic activities (lactase, alpha glucosidase, alkaline phosphatase). Its production of intestinal polyamines is one of its most relevant and specific mechanisms of action. The polyamines spermidine, spermine and putrescine boost the expression of brush border enzymes (such as hydrolases, proteases and transport molecules). Immune enhancement: S. boulardii helps prevent infection by stimulating the immune system along the GI lining, and it does this by increasing the protective antibody IgA. Anti-inflammatory: S. boulardii causes a decrease in pro-inflammatory cytokines.

Pregnancy & Breastfeeding

We don't have any information on whether Saccharomyces boulardii is safe to take during pregnancy or while breastfeeding.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: In adults with diarrhea associated with the use of antibiotics, Saccharomyces boulardii is used at 250 to 500 mg, two to four times a day. For diarrhea caused by Clostridium difficile, the dose is 1 gram daily for 4 weeks, along with antibiotic treatment. To reduce the symptoms of acute diarrhea, the dose is 250 mg twice a day for 5 days. For diarrhea in Crohn's disease, 250 mg three times daily has been used for up to 9 weeks. For diarrhea in ulcerative colitis, the dose is 250 mg three times daily. In infections due to Helicobacter pylori, 250 mg to 500 mg twice daily is given in addition to the usual treatment. For diarrhea in Irritable bowel syndrome (IBS), the dose is one 250 mg capsule twice daily. For traveler's diarrhea, the recommended dose is one 250 mg capsule per day. Children: to reduce the symptoms of acute diarrhea, children over three months are recommended to take two doses of 250 mg a day for five days. Children under three months are recommended to take 125 mg twice daily for five days.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.