Indications
Rabeprazole + Amoxicillin + Clarithromycin is used to clear H. pylori infection in people with active chronic gastric ulcer, duodenal ulcer or gastric ulcer.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Amoxicillin works like penicillin. It kills susceptible bacteria while they are actively multiplying, and it does this by blocking the building of the bacterial cell wall, which leads to the death of the bacteria.
Clarithromycin stops protein synthesis in susceptible organisms. It mainly binds to the donor site on the 50S subunit of the bacterial ribosome and prevents translocation to that site.
Rabeprazole belongs to a class of antisecretory compounds called substituted benzimidazole proton-pump inhibitors. These do not have anticholinergic or histamine H2-receptor antagonist properties. Instead, rabeprazole suppresses gastric acid secretion by inhibiting the gastric H+,K+ ATPase at the secretory surface of the gastric parietal cell. This enzyme is regarded as the acid (proton) pump within the parietal cell, so rabeprazole is described as a gastric proton-pump inhibitor. It blocks the final step of gastric acid secretion.
Pregnancy & Breastfeeding
Rabeprazole + Amoxicillin + Clarithromycin should be used in pregnancy only if the possible benefit to the mother justifies the possible risk. Amoxicillin passes into human milk, though only in very small amounts. Because nursing infants could have serious adverse reactions, a decision has to be made either to stop nursing or to stop the medicine, and that decision should take into account how important the treatment is for the mother.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.
Side Effects & Interactions
Side Effects
No side-effect data recorded yet.