Indications
Probiotic + Prebiotic + Vitamin K2-7 brings selected probiotic strains and nutrients together in a delayed-release vegetarian capsule, which carries them to the gut where they act. It is formulated to support kidney function, help gut health, and lower the risks linked with CKD. Probiotic + Prebiotic + Vitamin K2-7 may also help ease urinary tract conditions and support the removal of bacteria. It can be useful for protecting and detoxifying the urinary tract.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Probiotic
The probiotic strains Streptococcus thermophilus, Lactobacillus acidophilus, and Bifidobacterium longum act on nitrogenous wastes such as uric acid, creatinine, indoles, phenols, and nitrosamines. Their function is to break these wastes down. The wastes diffuse from the bloodstream into the bowel, where they are processed so that less of them builds up. The efficacy in chronic kidney disease (CKD) is significant, because the buildup of uremic toxins in the bloodstream goes down.
Bacillus subtilis HU58 is good for gut health. It helps reduce ammonia in the gut without promoting proteolytic fermentation, so less ammonia forms. For kidney support, it helps lower serum creatinine and urea levels, which gives significant benefits to CKD patients.
Prebiotic
Fructooligosaccharides (FOS) are a dietary fiber. Their prebiotic function is to promote the growth of beneficial bacteria, particularly Bifidobacteria, while inhibiting harmful pathogens like Clostridia. For colonic health, FOS lowers fecal pH, increases organic acids in the colon, and reduces the production of nitrogenous end products in urine and stool. FOS is also an energy source. When it ferments in the caecum and colon, it produces short-chain fatty acids (SCFA) like acetate, propionate, and butyrate, and these feed the colonocytes.
Vitamin K2-7
Vitamin K2-7 gives vascular protection by preventing vascular calcification, a common risk factor for cardiovascular events in CKD patients. Its efficacy is also higher, because among all forms of vitamin K, K2-7 has the highest bioavailability and the longest half-life, which makes it the most effective for humans. For cardiovascular benefits, it activates matrix Gla-protein (MGP), and this reduces the cardiovascular risks linked to vascular calcification in CKD patients.