Informational only — Not medical advice. Always consult a licensed healthcare provider.

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Polyethylene Glycol 3350 + Electrolytes

Osmotic purgatives Prescription
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Indications

Constipation

Polyethylene Glycol with electrolytes is used in adults and children over 12 years of age for effective relief from constipation and for treating chronic constipation. It is also effective in resolving fecal impaction. This is defined as refractory constipation with fecal loading of the rectum and colon.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Macrogol, also known as polyethylene glycol, works in the gut by osmosis, and this gives a laxative effect. It increases the volume of the stool, and the larger volume triggers movement of the colon through neuromuscular pathways. As a result, the softened stools are carried along the colon more easily and passing them becomes easier.

The electrolytes given together with Macrogol are exchanged with the serum electrolytes across the intestinal barrier (the mucosa). They are excreted without any net gain or loss of sodium, potassium and water. Macrogol itself stays unchanged as it passes along the gut, and it is virtually unabsorbed from the gastrointestinal tract.

Pregnancy & Breastfeeding

Macrogol (3350) is barely absorbed into the body, so no effects are expected during pregnancy. This oral solution can be used while you are pregnant.

The same applies to breastfeeding. Because the amount of Macrogol (3350) reaching a breastfeeding woman's bloodstream is negligible, no effects are expected on the breastfed newborn or infant. This oral solution can be used during breastfeeding.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: For adults and children aged 12 years and above, Polyethylene Glycol 3350 with electrolytes comes as a powder for suspension and as an oral solution. The doses differ a little, so they are given separately. Powder for suspension For constipation, the dose is 1 sachet daily. If needed, this may be increased to 2 to 3 sachets daily. For fecal impaction, take 8 sachets daily, all consumed within 6 hours. A course of treatment for fecal impaction does not normally exceed 3 days. Patients with renal insufficiency need no change in dose, whether the treatment is for constipation or for fecal impaction. Direction of use: dissolve each sachet in 125 ml of water. For fecal impaction, 8 sachets may be dissolved in 1 litre of water. Store the solution in a refrigerator and discard any that is not used within 6 hours. Oral solution For constipation, add 25 ml of Polyethylene Glycol 3350 and electrolytes oral solution to 100 ml of water and take it once daily (this makes a total volume of 125 ml). If needed, according to individual response, this may be increased to 2 to 3 doses of 25 ml daily, with each 25 ml dose added to 100 ml of water. For fecal impaction, take 8 doses of 25 ml daily, each 25 ml dose added to 100 ml of water. A course of treatment for fecal impaction does not normally exceed 3 days. Direction of use: add 25 ml of the oral solution to 100 ml of water, to make a total volume of 125 ml. Discard any diluted solution that is left unused within 24 hours.