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Phenylephrine + Promethazine

Sedating Anti-histamine Prescription

Indications

Promethazine hydrochloride and Phenylephrine hydrochloride syrup is used for the short-term relief of upper respiratory symptoms, including a blocked nose, that come with an allergy or the common cold.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Phenylephrine is a potent agonist of the postsynaptic α-receptors. Its main action is to narrow the blood vessels in the lining of the nose, and this relieves the nasal congestion that comes with allergies or head colds. Promethazine blocks H1 receptors. Besides its antihistamine action, it has useful sedative and antiemetic effects in clinical practice.

Pregnancy & Breastfeeding

Phenylephrine and Promethazine falls under Pregnancy Category C. No adequate, well-controlled studies of promethazine have been done in pregnant women. So the medicine should be used during pregnancy only if the likely benefit justifies the possible risk to the fetus.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Adults and children 12 years and over can take 1 teaspoonful (5 mL) every 4 to 6 hours. They should not go beyond 6 teaspoonsful (30 mL) in 24 hours. For children 6 to under 12 years of age, the dose is ½ to 1 teaspoonful (2.5 to 5 mL) every 4 to 6 hours, again with a limit of 6 teaspoonsful (30 mL) in 24 hours. Children 2 to under 6 years of age take ¼ to ½ teaspoonful (1.25 to 2.5 mL) every 4 to 6 hours. Children under 2 years of age should not be given Promethazine and Phenylephrine, as they are not recommended for this age group.

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Phenylephrine + Promethazine

Indications

Pharmacology

Pregnancy & Breastfeeding

Dosage Reference

Side Effects & Interactions

Side Effects

Key Interactions