Pentoxifylline
Indications
Pentoxifylline is used for several circulation problems. It is prescribed for peripheral arterial occlusive disease (PAOD) that has arteriosclerotic or diabetic origin. This includes intermittent claudication, where the legs ache or cramp when walking, and rest pain. It is also used for trophic lesions such as leg ulcers and gangrene. Other uses include cerebral vascular diseases and circulatory disturbances of the eye, when these come with degenerative vascular disorders.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Pentoxifylline and its metabolites improve the flow properties of blood by reducing its viscosity. In patients with chronic peripheral arterial disease, this increases blood flow to the affected microcirculation and improves tissue oxygenation. The exact mechanism of action of pentoxifylline and the sequence of events leading to clinical improvement have not yet been fully defined. Administration of pentoxifylline has been shown to produce dose related hemorrheologic effects, lowering blood viscosity and improving the flexibility of red blood cells. Studies in animals and in vitro studies in humans have shown changes in leukocyte properties of hemorrheologic importance. Pentoxifylline has been shown to increase the deformability of leukocytes and to inhibit the adhesion and activation of neutrophils. Therapeutic doses of pentoxifylline have been shown to significantly raise tissue oxygen levels in patients with peripheral arterial disease.
Pregnancy & Breastfeeding
Insufficient experience has been gained concerning use in pregnancy. Therefore, it is recommended that Pentoxifylline is not used during pregnancy. Pentoxifylline passes into breast milk in minute quantities. Because insufficient experience has been gained, the physician must carefully weigh the possible risks and benefits before administering Pentoxifylline in breast-feeding women.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.
Side Effects & Interactions
Side Effects
No side-effect data recorded yet.