Informational only — Not medical advice. Always consult a licensed healthcare provider.

Shasthya স্বাস্থ্য · Health, made simple
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Community data Updated 23 hours ago
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Indications

Fungal Infection Vaginal Candidiasis

Oteseconazole is used to reduce how often recurrent vulvovaginal candidiasis (RVVC) comes back. It is meant for females who have a history of RVVC and who are not of reproductive potential. You can start antifungal treatment before the fungal culture results are ready, if specimens were taken before therapy. Once the results are available, the antifungal treatment should be adjusted to match them.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Oteseconazole is an antifungal medicine. How its effect relates to the dose or level in the body, and how the response changes over time, are not known.

It is an azole metalloenzyme inhibitor and it acts on a fungal sterol enzyme, 14α demethylase (CYP51). This enzyme catalyzes an early step in making ergosterol, a sterol that fungal cell membranes need to form and stay intact. When CYP51 is blocked, 14-methylated sterols build up, and some of these are toxic to fungi. Oteseconazole contains a tetrazole metal-binding group, and because of this it has a lower affinity for human CYP enzymes.

Pregnancy & Breastfeeding

Oteseconazole must not be used by pregnant women or by females of reproductive potential. Animal studies show it may cause fetal harm when given to a pregnant woman. The drug also stays in the body for about 690 days (this is 5 times its half-life), and that long exposure window means the risk to the embryo and fetus cannot be adequately reduced.

Oteseconazole is also contraindicated in women who are breastfeeding. There are no data on whether oteseconazole passes into human or animal milk, and none on its effect on milk production. No adverse effects were reported in breastfed infants whose mothers were exposed to oteseconazole during lactation. However, the infants were followed up for only a short time after birth, so no conclusions can be drawn from these data.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Oteseconazole has two recommended dosage regimens. For the Oteseconazole-only regimen, give Oteseconazole 600 mg as a single dose on Day 1. On Day 2, give 450 mg as a single dose. Then, beginning on Day 14, give 150 mg once a week (every 7 days) for 11 weeks (Weeks 2 through 12). For the Fluconazole/Oteseconazole regimen, prescribe fluconazole along with it. Give fluconazole 150 mg orally on Day 1, Day 4 and Day 7. Then give Oteseconazole 150 mg once daily for 7 days, on Days 14 through 20. After that, beginning on Day 28, give Oteseconazole 150 mg once a week (every 7 days) for 11 weeks (Weeks 4 through 14). Oteseconazole should be taken orally with food. Swallow the capsules whole. Do not chew, crush, dissolve or open them.