Indications
Ospemifene is an estrogen agonist/antagonist. Doctors use it to treat moderate to severe dyspareunia (pain during sexual intercourse), which is a symptom of vulvar and vaginal atrophy due to menopause.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Ospemifene is a newer selective estrogen receptor modulator (SERM). It binds to estrogen receptors and, depending on the type of tissue, either stimulates or blocks the action of estrogen. In the endometrium, it has an agonistic effect.
Pregnancy & Breastfeeding
Use in Pregnancy: Ospemifene must not be used by women who are or may become pregnant. If it is used during pregnancy, or if a woman becomes pregnant while taking it, she should be told about the possible harm to the fetus. Based on animal data, Ospemifene is likely to increase the risk of adverse outcomes during pregnancy and labor. At doses that were toxic to the mother, the adverse findings included embryo fetal lethality in rats and rabbits, and neonatal mortality and difficult labor in rats. These reproductive effects fit with the estrogen receptor activity of Ospemifene and are considered to be related to it.
Use in Lactation: It is not known whether Ospemifene passes into human breast milk. There are no data on how it affects the breastfed child or milk production. Do not breastfeed while taking Ospemifene. The medicine was found in rat milk.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.
Side Effects & Interactions
Side Effects
No side-effect data recorded yet.