Informational only — Not medical advice. Always consult a licensed healthcare provider.

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Community data Updated 23 hours ago
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Indications

Asthma Urticaria Allergy

Asthma: Omalizumab is used in adults and children aged 6 years and older who have moderate to severe persistent asthma. These patients must have a positive skin test or in vitro reactivity to a perennial aeroallergen, and their symptoms must not be well controlled with inhaled corticosteroids. Nasal Polyps: Omalizumab is used as an add-on maintenance treatment for nasal polyps in adults aged 18 years and older who have not responded well enough to nasal corticosteroids. Chronic Spontaneous Urticaria (CSU): Omalizumab is used to treat adults and adolescents aged 12 years and older with chronic spontaneous urticaria who still have symptoms despite H1 antihistamine treatment.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

In asthma and nasal polyps, omalizumab stops IgE from binding to the high-affinity IgE receptor (FcεRI) on the surface of mast cells, basophils and dendritic cells. This leads to FcεRI down-regulation on these cells. In people with allergic asthma, treatment with omalizumab inhibits IgE-mediated inflammation. You can see this in the reduced blood and tissue eosinophils and in the reduced inflammatory mediators, including IL-4, IL-5 and IL-13.

In chronic spontaneous urticaria (CSU), omalizumab binds to IgE and lowers free IgE levels. After that, the IgE receptors (FcεRI) on cells down-regulate. How these effects improve CSU symptoms is not known.

Pregnancy & Breastfeeding

Asthma that is poorly or only moderately controlled carries risks in pregnancy. There is no information on whether omalizumab passes into human milk, or on what it does to milk production. Omalizumab is a human monoclonal antibody (IgG1 kappa), though, and immunoglobulin (IgG) is present in human milk in small amounts.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Omalizumab is given by subcutaneous (SC) injection only. If a dose is more than 150 mg, split it between more than one injection site so that no site gets more than 150 mg. Asthma: the dose is 75 to 375 mg SC every 2 or 4 weeks. The dose (mg) and how often it is given depend on the serum total IgE level (IU/mL), measured before treatment starts, and on body weight (kg). The dose determination charts should be checked. Nasal polyps: the dose is 75 to 600 mg SC every 2 or 4 weeks. Here too, the dose (mg) and the frequency depend on the serum total IgE level (IU/mL), measured before treatment starts, and on body weight (kg). Again, see the dose determination charts. Chronic spontaneous urticaria (CSU): the dose is 150 or 300 mg SC every 4 weeks. In CSU, the dose doesn't depend on serum IgE level or body weight.