Indications
Naproxen Sodium + Esomeprazole Magnesium tablet is used to relieve the signs and symptoms of osteoarthritis, rheumatoid arthritis and ankylosing spondylitis. It is also used to lower the risk of gastric ulcers in patients who are at risk of developing NSAID-associated gastric ulcers.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
This combination tablet has two parts: an immediate-release layer of Esomeprazole Magnesium and an enteric-coated core of Naproxen. So the Esomeprazole is released first, in the stomach, and the Naproxen dissolves later in the small intestine.
Naproxen is an NSAID with analgesic and antipyretic properties. It works by inhibiting prostaglandin synthesis. Esomeprazole is a proton pump inhibitor that suppresses gastric acid secretion. It does this by specifically inhibiting the H+/K+ -ATPase in the gastric parietal cell. By acting on the proton pump, Esomeprazole blocks the final step in acid production, and so gastric acidity is reduced.
Pregnancy & Breastfeeding
Pregnancy: If a woman is trying to conceive, or is in the first or second trimester of pregnancy, the Naproxen and Esomeprazole tablet should not be given unless the likely benefit to the patient outweighs the possible risk to the foetus. In the third trimester of pregnancy, the tablet is contraindicated.
Breast-feeding: Naproxen passes into human milk in low quantities. It is not known whether esomeprazole passes into human milk. The Naproxen and Esomeprazole tablet should not be used during breastfeeding.
Fertility: NSAIDs like Naproxen may impair female fertility. For this reason, the Naproxen and Esomeprazole tablet is not recommended for women who are trying to conceive.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.
Side Effects & Interactions
Side Effects
No side-effect data recorded yet.