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Community data Updated 22 hours ago

Nab-Paclitaxel [Nanoparticle Albumin-Bound Paclitaxel]

Cytotoxic Chemotherapy Prescription
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Indications

Cancer

Metastatic breast cancer Nab-Paclitaxel [Nanoparticle Albumin-Bound Paclitaxel] is used to treat breast cancer when combination chemotherapy for metastatic disease has failed, or when the cancer has relapsed within 6 months of adjuvant chemotherapy. The earlier treatment should have included an anthracycline, unless that was clinically contraindicated. Non-small cell lung cancer Nab-Paclitaxel is used as first-line treatment for locally advanced or metastatic non-small cell lung cancer. It is given together with carboplatin, in patients who are not candidates for curative surgery or radiation therapy. Adenocarcinoma of the pancreas For patients with metastatic adenocarcinoma of the pancreas, the medicine is used as first-line treatment in combination with gemcitabine.

⚠️ Always consult a registered physician before taking any medicine.

Pregnancy & Breastfeeding

Nab-Paclitaxel is Pregnancy Category D, which means it can cause harm to the baby when given to a pregnant woman. In rats, albumin-bound paclitaxel given during pregnancy at doses lower than the maximum recommended human dose (based on body surface area) caused toxicity to the embryo and fetus. This included intrauterine mortality, increased resorptions, fewer live fetuses and malformations.

There are no adequate and well-controlled studies in pregnant women taking Nab-Paclitaxel. If the medicine is used during pregnancy, or if a patient becomes pregnant while on it, she should be told about the possible hazard to the baby. Women who could become pregnant should be advised to avoid pregnancy while receiving Nab-Paclitaxel.

It is not known whether paclitaxel passes into human milk. In lactating rats, paclitaxel and/or its metabolites were found in the milk. Many drugs pass into human milk, and nursing infants could have serious adverse reactions. So a decision should be made either to stop nursing or to stop the drug, taking into account how important the drug is to the mother.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Metastatic Breast Cancer Nab-Paclitaxel is used after combination chemotherapy has failed for metastatic breast cancer, or when the cancer has relapsed within 6 months of adjuvant chemotherapy. The recommended regimen is 260 mg/m² given intravenously over 30 minutes every 3 weeks. Non-Small Cell Lung Cancer The recommended dose is 100 mg/m², given as an intravenous infusion over 30 minutes on Days 1, 8, and 15 of each 21-day cycle. Carboplatin is given on Day 1 of each 21 day cycle, immediately after the Nab-Paclitaxel. Adenocarcinoma Of The Pancreas The recommended dose is 125 mg/m², given as an intravenous infusion over 30 to 40 minutes on Days 1, 8 and 15 of each 28-day cycle. Gemcitabine follows immediately after the infusion on Days 1, 8 and 15 of each 28-day cycle. Dosage In Patients With Hepatic Impairment For patients with mild hepatic impairment (total bilirubin greater than ULN and less than or equal to 1.5 x ULN, and aspartate aminotransferase [AST] less than or equal to 10 x ULN), no dose adjustment is required, whatever the indication. Don't give Nab-Paclitaxel to patients with metastatic adenocarcinoma of the pancreas who have moderate to severe hepatic impairment. Don't give it either to patients with total bilirubin greater than 5 x ULN or AST greater than 10 x ULN, whatever the indication, because these patients have not been studied.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.