Myo-inositol

Inositols are important molecules for female fertility and for sustaining a physiological pregnancy. Myo-inositol is a major form of inositol and has an established role in human physiology. It is the most abundant inositol isomer in humans and is commonly found in almost every tissue, particularly the brain, blood, fat, kidney, lung, ovaries and testes, where it takes part in several cellular pathways. Acting as a second messenger of gonadotropins and insulin, it guarantees the correct development of oocytes and the progression of embryogenesis. Available evidence shows that supplementation with myo-inositol raises the probability of achieving pregnancy and reduces the onset of adverse maternal effects and neonatal outcomes. For women trying to conceive, it has been shown to induce ovulation and restore the physiological menstrual cycle in infertile women, particularly those with Polycystic ovary syndrome (PCOS). It is also useful for women undergoing Assisted reproductive technology (ART), because it improves oocyte and embryo quality. During pregnancy, myo-inositol reduces the risk of altered metabolic conditions like Gestational Diabetes Mellitus (GDM), which may lead to miscarriages or stillborn babies. It also seems to reduce the risk of Neural tube defects (NTDs) in folate-resistant women.