Informational only — Not medical advice. Always consult a licensed healthcare provider.

Community data Updated 23 hours ago

Indications

Prophylaxis of organ rejection in kidney transplant Mycophenolic acid is used to prevent organ rejection in adults who have received a kidney transplant. It is also used for the same purpose in children aged 5 years and older who are at least 6 months past their kidney transplant. Limitations of use Mycophenolic acid delayed-release tablets and mycophenolate mofetil tablets and capsules should not be swapped for one another unless a physician is supervising, because the two products are not absorbed at the same rate.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Mycophenolic acid delayed-release tablets are an enteric coated form of mycophenolate sodium, and they deliver the active part of the medicine, mycophenolic acid. It is an immunosuppressive agent. It works as an uncompetitive and reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH). Because of this, it blocks the de novo pathway of guanosine nucleotide synthesis, and it does so without being incorporated into DNA. Mycophenolic acid has cytostatic effects on lymphocytes. It has been shown to prevent acute rejection of kidney and heart allotransplantation, and it also decreases antibody production.

Pregnancy & Breastfeeding

Mycophenolic acid is Pregnancy Category D, which means it can cause harm to the unborn baby. A mother has to choose between stopping Mycophenolic acid and stopping breastfeeding, both while she is on treatment and for 6 weeks after the treatment ends. The doctor should weigh how important the medicine is for the mother when making this choice.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: The recommended dosage of Mycophenolic acid in adult kidney transplant patients is 720 mg twice daily (1440 mg total daily dose). For pediatric kidney transplant patients in conversion (at least 6 months post-transplant) who are 5 years and older, the dosage is 400 mg/m2 body surface area (BSA) twice daily, up to a maximum of 720 mg twice daily. A child with a BSA of 1.19 to 1.58 m2 may take three Mycophenolic acid 180 mg tablets, or one 180 mg tablet plus one 360 mg tablet, twice daily (1080 mg daily dose). If the BSA is >1.58 m2, the child may take four 180 mg tablets, or two 360 mg tablets, twice daily (1440 mg daily dose). Take the tablets on an empty stomach, either 1 hour before or 2 hours after food. Don't crush, chew or cut them before swallowing. They should go down whole so the enteric coating stays intact.

Side Effects & Interactions