Informational only — Not medical advice. Always consult a licensed healthcare provider.

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Community data Updated 2 months ago
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Indications

Depression

Mirez Tablets are used to treat major depressive disorder (MDD).

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Pharmacodynamics: Nobody knows exactly how Mirtazapine works, and this is true of many other medicines used to treat major depressive disorder. Studies done before human use suggest that Mirtazapine increases the activity of noradrenaline and serotonin in the central nervous system. These studies show that Mirtazapine blocks central presynaptic α2-adrenergic inhibitory autoreceptors and heteroreceptors, and this is thought to lead to more noradrenergic and serotonergic activity in the brain. Mirtazapine is a strong blocker of 5-HT2 and 5-HT3 receptors but has no meaningful affinity for the 5-HT1A and 5-HT1B receptors. It is also a strong blocker of histamine (H1) receptors, which may account for its marked sedative effect. Outside the brain, Mirtazapine moderately blocks peripheral α1-adrenergic receptors, which may explain the occasional drop in blood pressure on standing that has been reported with its use. Its moderate action on muscarinic receptors may be the reason anticholinergic side effects are fairly uncommon with this medicine.

Pharmacokinetics: After Mirtazapine tablets are taken by mouth, the active ingredient, mirtazapine, is absorbed quickly and well, and reaches its peak plasma level in about 2 hours. About 85% of mirtazapine binds to plasma proteins. The mean elimination half-life is 20 to 40 hours (26 hours in males and 37 hours in females), which is long enough to allow once-a-day dosing. Within the recommended dose range, mirtazapine's pharmacokinetics are linear. The body breaks Mirtazapine down extensively, and it is cleared through the urine and faeces over four days. The main routes of biotransformation are demethylation and oxidation, followed by conjugation.

Pregnancy & Breastfeeding

Pregnancy Category C. Patients on Mirtazapine should tell their doctor right away if they become pregnant, are planning a pregnancy, or are breastfeeding an infant.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: The usual starting dose of mirtazapine tablets for adults is 15 mg a day, taken once, preferably in the evening or just before sleep. Most people are treated with a dose between 15 and 45 mg a day. If there is no response at 15 mg, the dose may be raised to 30 mg, and up to a maximum of 45 mg a day. Mirtazapine stays in the body for a long time, with an elimination half-life of about 20 to 40 hours. Because of this, the dose should not be changed more often than every 1 to 2 weeks. That gap gives the body enough time to show its response to a given dose. Mirtazapine is not recommended for use in children. If you miss a dose of mirtazapine, take it as soon as you remember, unless it is nearly time for the next dose. If it is close to the time of the next dose, skip the missed one and take the next dose at the usual time. Never take a double dose or more than the dose your doctor has prescribed.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.