Mifepristone + Misoprostol

Adults: Only a qualified medical professional should prescribe Mifepristone + Misoprostol. This person must be able to assess the gestational age of an embryo and to diagnose ectopic pregnancies. They must also be able to provide surgical intervention/MVA (Manual Vaccum Aspiration) in cases of incomplete abortion or severe bleeding, or have made plans to provide such care through others. They must be able to assure the patient access to medical facilities equipped to provide blood transfusions and resuscitation, if necessary. Day 1 (First visit): Mifepristone administration. One tablet of Mifepristone (200 mg) is taken as a single oral dose, under the supervision of a qualified medical professional in a clinic, medical office or hospital. Day 2 (Second visit): Misoprostol administration. At 24 to 48 hours after the Mifepristone tablet is taken, the patient takes four 200 microgram tablets (800 micrograms) of Misoprostol, buccally or sublingually. She can take the Misoprostol tablets herself, placing two tablets on each side between the cheek and gum, or under the tongue. She should then wait for 30 minutes. Right after taking Misoprostol, she may need medicine for cramps or gastrointestinal symptoms. She should be told what to do if significant discomfort, excessive bleeding or other adverse reactions occur, and she should be given a phone number to call if she has questions after taking Misoprostol. Day 10 to 14 (Third visit): Post-treatment examination. Patients must return to the clinic, medical office or hospital within 10 to 14 days after taking Mifepristone. This visit is very important, because it confirms by clinical examination or ultrasonographic scan that the termination of pregnancy is complete. Patients who still have an ongoing pregnancy at this visit have a risk of fetal malformation resulting from the treatment. Surgical termination/MVA is recommended to manage Menstrual Regulation (MR)/termination of pregnancy failures.