Miconazole Nitrate + Hydrocortisone
Indications
Miconazole Nitrate + Hydrocortisone is used on the skin for inflamed dermatoses where an infection by susceptible organisms and inflammation are both present, for example intertrigo and infected eczema. It is also used for moist or dry eczema or dermatitis, including atopic eczema, primary irritant or contact allergic eczema, and seborrheic eczema, including the kind associated with acne. It can be used for interiginous eczema too, including inflammatory interigo, and for perianal and genital dermatitis. The organisms that miconazole works against are dermatophytes and pathogenic yeasts (e.g. Candida spp.). Many Gram-positive bacteria are also susceptible, including many strains of Streptococcus and Staphylococcus.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Miconazole is a substituted imidazole and belongs to the azole family of medicines. It is used for superficial candidiasis and for skin infections such as dermatophytosis, pityriasis versicolor, acanthameaba and seborrhoic dermatitis. It is also active against Aspergillus spp., Cryptococcus neoformans, Pseudalescheria boydii and some gram-positive bacteria, including Staphylococci and Streptococci.
Hydrocortisone is a naturally occurring glucocorticoid, though it is now made synthetically. Its main function is in skin injury such as inflammation. It also has antipruritic, antimycotic and vasoconstrictive activity.
Miconazole is an imidazole antifungal agent that interferes with ergosterol synthesis. This changes the permeability of the cell membrane of sensitive fungi and so kills them. When Miconazole Nitrate + Hydrocortisone is applied to the skin, the hydrocortisone is absorbed into the skin cells. There it prevents the release of certain chemicals that cause inflammation, and that is how hydrocortisone reduces inflammation.
Pregnancy & Breastfeeding
When pregnant animals were given corticosteroids at high doses, abnormal development of the fetus was seen. So topical steroids, such as the miconazole nitrate and hydrocortisone combination, should not be used extensively in pregnancy.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.
Side Effects & Interactions
Side Effects
No side-effect data recorded yet.