Metolazone

Adults: Effective dosage of Metolazone should be individualized according to indications and patient response. A single daily dose is recommended. Therapy with Merozolyn should be titrated to gain an initial therapeutic response and to determine the minimal dose possible to maintain the desired therapeutic response. Usual dosages: for edema of cardiac failure, Metolazone 5 to 10 mg is given once daily. For edema of renal disease, Metolazone 5 to 20 mg is given once daily. Treatment of edematous states: the time interval for the initial dosage to show effect may vary; diuresis and saluresis usually begin within one hour and persist for 12 to 24 hours, depending on dosage. When a desired therapeutic effect has been obtained, it may be advisable to reduce the dose, if possible. The daily dose depends on the severity of the patient's condition, sodium intake and responsiveness. A decision to change the daily dose should be based upon the results of thorough clinical and laboratory determinations. If antihypertensive drugs or diuretics are given concurrently with Merozolyn, more careful dosage adjustment may be necessary. For patients with congestive cardiac failure who tend to experience paroxysmal nocturnal dyspnea, it is usually advisable to employ a dosage near the upper end of the range to ensure prolongation of diuresis and saluresis for a full 24 hour period. Hypertension: for mild to moderate essential hypertension, Metolazone 2.5 to 5 mg is given once daily. Treatment of hypertension: the time interval required for the initial dosage regimen of Metolazone to show effect may vary from three to four days, to three to six weeks, in the treatment of elevated blood pressure. Doses should be adjusted at appropriate intervals to achieve maximum therapeutic effect.