Lynestrenol

Adults: Dosage Polymenorrhoea: Take 1 tablet daily on days 14 to 25 of the cycle. Premenstrual syndrome: Take 1 tablet daily on days 4 to 25 of the cycle. Endometriosis: Take 1 to 2 tablets daily for at least 6 months. Selected cases of endometrial carcinoma: Take 6 to 10 tablets daily for prolonged periods. Benign breast disease: Take 1 tablet daily on days 14 to 25 of the cycle for at least 3 to 4 months. Menorrhagia and metrorrhagia: Take 1 tablet daily on days 14 to 25 of the cycle; bleeding usually ceases within a few days after starting treatment. The course is then repeated for the next 3 menstrual cycles, with 1 tablet taken daily on days 14 to 25 of each cycle. If the complaints do not disappear during or after this treatment, further diagnostic evaluation is needed. Selected cases of primary and secondary amenorrhoea and oligomenorrhoea: Treatment should begin with an estrogen, for example 0.02 to 0.05 mg of ethinylestradiol daily for 25 days. Alongside this, 1 tablet of Lynestrenol is taken daily on days 14 to 25. Withdrawal bleeding usually occurs within 3 days after treatment stops. Treatment is then resumed for a second cycle starting on day 5 of this withdrawal bleeding, with the estrogen given on days 5 to 25 of the cycle and Lynestrenol again taken as 1 tablet daily on days 14 to 25. This course should be repeated for at least one more cycle. Suppression of menstruation, ovulation, and ovulation pain (dysmenorrhoea): Treatment with 1 tablet daily should ideally start on day 1 of the cycle, and no later than day 5. It can be continued for many months without tablet free days. If breakthrough bleeding occurs despite treatment, the dose should be raised to 2 or 3 tablets daily for 3 to 5 days. Postponement of menstruation: Treatment with 1 tablet daily should ideally start 2 weeks before menstruation is expected. If started less than 1 week before the expected onset, the dose should be 2 to 3 tablets daily, though in that case a delay of more than 1 week is not advisable. Starting treatment later raises the risk of breakthrough bleeding, so it should not begin later than 3 days before the expected onset of menstruation. As an adjunct to estrogen therapy in the pre and postmenopausal period, to help prevent endometrial hyperplasia: Take half to 1 tablet daily for 12 to 15 days each month, for example during the first 2 weeks of every calendar month, while the estrogen is given daily without tablet free intervals at the lowest effective dose.