Informational only — Not medical advice. Always consult a licensed healthcare provider.

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Community data Updated 2 months ago
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Indications

Lopinavir with Ritonavir is an HIV-1 protease inhibitor combination. It is used together with other antiretroviral medicines to treat HIV-1 infection in adults and in children aged 14 days and older.

⚠️ Always consult a registered physician before taking any medicine.

Pregnancy & Breastfeeding

Nursing mothers: The Centers for Disease Control and Prevention recommend that mothers infected with HIV-1 do not breastfeed their babies, because of the risk of passing HIV-1 on after birth. In studies in rats, lopinavir was found in milk. It is not known whether lopinavir passes into human milk. Since there is a risk of HIV-1 transmission and also a risk of serious side effects in breastfed infants, mothers taking this combination should be told not to breastfeed.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Lopinavir and Ritonavir tablets can be taken with or without food. Swallow them whole. Don't chew, break or crush them. For adults, the dose is 400/100 mg (two 200/50 mg tablets) twice daily. The other option is 800/200 mg (four 200/50 mg tablets) once daily, and this is only for patients with fewer than three lopinavir resistance-associated substitutions. If an adult is also taking efavirenz, nevirapine or nelfinavir, the dose of Lopinavir and Ritonavir may need to be adjusted. Do not use once daily administration of Lopinavir and Ritonavir in HIV-1 infected patients who have three or more of these lopinavir resistance-associated substitutions: L10F/I/R/V, K20M/N/R, L24I, L33F, M36I, I47V, G48V, I54L/T/V, V82A/C/F/S/T and I84V. Do not use it once daily in combination with efavirenz, nevirapine, nelfinavir, carbamazepine, phenobarbital or phenytoin either.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.