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Linagliptin + Metformin Hydrochloride

Combination Oral hypoglycemic preparations Prescription
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Indications

Type 2 Diabetes Mellitus Diabetes Mellitus

Linagliptin + Metformin Hydrochloride is used along with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus. It suits people for whom treatment with both Linagliptin and Metformin Hydrochloride is appropriate.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Linagliptin is used to improve blood sugar control in people with type 2 diabetes mellitus. It blocks DPP-4 (dipeptidyl peptidase-4), an enzyme that breaks down the incretin hormones GLP-1 (glucagon like peptide-1) and GIP (glucose dependent insulinotropic polypeptide). With the enzyme blocked, linagliptin raises the level of active incretin hormones. These hormones stimulate the pancreatic beta (β) cells to release insulin, and they do so in a glucose-dependent manner. They also reduce the amount of glucagon that the pancreatic alpha (α) cells release into the circulation.

Metformin Hydrochloride is a biguanide type of oral antihyperglycemic medicine, used in the management of type 2 diabetes. It lowers both basal and postprandial plasma glucose. Its mechanism of action is different from that of the sulfonylureas, and it does not produce hypoglycemia. Metformin Hydrochloride decreases hepatic glucose production and decreases intestinal absorption of glucose. It also improves insulin sensitivity by increasing peripheral glucose uptake and utilization.

Pregnancy & Breastfeeding

No adequate and well-controlled studies have been done in pregnant women with linagliptin and metformin hydrochloride together, or with either medicine on its own. So the combination should be used during pregnancy only if it is clearly needed. Take care too when giving it to a breastfeeding mother.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Linagliptin and Metformin immediate release tablet: the dose should be set for each patient, based on how well it works and how well the patient tolerates it. The maximum recommended dose is 2.5 mg Linagliptin and 1000 mg Metformin Hydrochloride twice daily with meals. The dose should be increased gradually, to reduce the gastrointestinal (GI) side effects that come with Metformin Hydrochloride. Recommended starting dose: in patients not currently treated with Metformin Hydrochloride, start with 2.5 mg Linagliptin and 500 mg Metformin Hydrochloride twice daily. In patients already treated with Metformin Hydrochloride, start with 2.5 mg Linagliptin and the current dose of Metformin Hydrochloride, twice daily. Patients already taking Linagliptin and Metformin Hydrochloride as separate medicines may be switched to this combination, with the same dose of each component. Linagliptin and Metformin extended release tablet: the dose should be set for each patient, based on how well it works and how well the patient tolerates it. The total daily dose must not go above the maximum recommended, which is Linagliptin 5 mg and Metformin Hydrochloride 2000 mg. This combination should be given once daily with a meal. Recommended starting dose: in patients not currently treated with Metformin, start with 5 mg Linagliptin and 1000 mg Metformin Hydrochloride extended-release once daily with a meal. In patients already treated with Metformin, start with a total daily dose of 5 mg Linagliptin and a similar total daily dose of Metformin, once daily with a meal. In patients already treated with the Linagliptin and Metformin immediate release tablet, switch to the extended release tablet that gives a total daily dose of 5 mg Linagliptin and a similar total daily dose of Metformin, once daily with a meal. The 5 mg Linagliptin and 1000 mg Metformin Hydrochloride extended-release tablet is taken as a single tablet once daily. Patients using the 2.5 mg Linagliptin and 1000 mg Metformin extended release tablets should take two tablets together once daily.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.