Levocetirizine Dihydrochloride

Adults: Adults and children 12 years of age and older should take 5 mg of Levocetirizine once daily. Children 6 to 11 years of age: the recommended dose is 2.5 mg once daily. This is ½ tablet or 1 teaspoon of the oral solution. Children 6 months to 5 years of age: the recommended dose is 1.25 mg once daily, which is ½ teaspoon of the oral solution. Pediatric use: for the uncomplicated skin manifestations of chronic idiopathic urticaria in patients 6 months to 17 years of age, the dose is based on extrapolation of efficacy from adults 18 years of age and older. Geriatric use: the clinical studies did not include enough patients aged 65 years and older for each approved indication to show whether they respond differently from younger patients. Hepatic impairment: no dosage adjustment is required in patients with solely hepatic impairment. Renal impairment depends on how severe it is: Mild renal impairment (creatinine clearance 50 to 80 ml/min): 2.5 mg once daily is recommended. Moderate renal impairment (creatinine clearance 30 to 50 ml/min): 2.5 mg once every other day is recommended. Severe renal impairment (creatinine clearance 10 to 30 ml/min): 2.5 mg twice weekly, given once every 3 to 4 days, is recommended. Patients with end-stage renal disease (creatinine clearance below 10 ml/min) and patients undergoing hemodialysis should not receive Levocetirizine.