Leuprorelin Acetate

Indications

Prostate Cancer Leuprorelin Acetate 3 Month 11.25 mg is indicated for the palliative treatment of advanced prostatic cancer. It gives another option when orchiectomy or estrogen administration is either not indicated or not acceptable to the patient. Endometriosis The 3 month 11.25 mg strength is indicated for treating endometriosis for a period of six months. You can use it as the only therapy, or as an adjunct to surgery. Uterine Fibroids It is also indicated for leiomyoma uteri (uterine fibroids), for a period up to six months. The therapy may be given before myomectomy or hysterectomy, or it may give symptomatic relief to a perimenopausal woman who does not want surgery. Breast Cancer Leuprorelin Acetate 3 month 11.25 mg is also indicated for treating breast cancer in pre- and peri-menopausal women in whom hormone therapy is specified.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Leuprorelin acetate is a GnRH agonist. Given continuously and in therapeutic doses, it acts as a potent inhibitor of gonadotropin secretion. Animal and human studies show that after an initial stimulation, chronic administration of leuprorelin acetate results in suppression. Administration has also resulted in inhibition of the growth of certain hormone dependent tumors (prostatic tumors in Nobel and Dunning male rats, and DMBA-induced mammary tumors in female rats), as well as atrophy of the reproductive organs. In humans, the first effect is a rise in circulating levels of luteinizing hormone (LH) and follicle stimulating hormone (FSH). This leads to a transient increase in the gonadal steroids (testosterone and dihydrotestosterone in males, and estrone and estradiol in pre-menopausal females). With continuous administration, however, the levels of LH, FSH and the sex steroids go down. In males, testosterone is reduced to castrate or prepubertal levels. In pre-menopausal females, estrogens are reduced to post-menopausal levels. These hormonal changes occur within a month of starting therapy at recommended doses.

Pregnancy & Breastfeeding

Nobody knows yet whether leuprorelin acetate passes into human breast milk. Because of this, nursing mothers should not use leuprorelin acetate.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Leuprorelin Acetate 3 Month 11.25 mg must be given under the supervision of a physician. Once reconstituted, the suspension should be discarded if it isn't used immediately. As with other injected medicines, the injection sites should be varied from time to time. Reconstitute the microspheres just before giving the injection. The dose of 3 Month 11.25 mg is a single subcutaneous or intramuscular injection every three months. For endometriosis, therapy should begin on the first day of the menstrual cycle, after pregnancy has been ruled out. Amenorrhea usually shows that the patient is responding clinically, although spotting or bleeding from the atrophic endometrium can still occur. For uterine fibroids, the recommended duration of therapy is up to 6 months.