Informational only — Not medical advice. Always consult a licensed healthcare provider.

Community data Updated 23 hours ago

Indications

Lactitol Monohydrate is used to treat chronic idiopathic constipation (CIC). It is also used in acute and chronic portal systemic encephalopathy.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Lactitol Monohydrate is a disaccharide derivative made up of galactose and sorbitol. The body absorbs very little of it, and the disaccharidases in the GIT don't hydrolyse it, so it reaches the colon unchanged. There the intestinal flora break it down into short chain, low molecular weight organic acids. This raises the osmotic pressure in the colon, which increases the water content and volume of the stool, and that is how the laxative effect comes about. Lactitol Monohydrate works in the lumen of the colon, where it is virtually 100% bioavailable. Only minimal amounts are absorbed, and up to 2% can be found unchanged in the urine.

Pregnancy & Breastfeeding

Very little lactitol is absorbed into the body after it is taken by mouth, so it isn't known whether a mother's use of lactitol would expose the baby in the womb to the drug. There are no data on whether lactitol passes into human or animal milk. The effects on a breastfed infant and on milk production are also not known.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Lactitol can be mixed with hot or cold drinks, puddings and similar foods. The dose will need adjusting to get one bowel movement a day in constipated patients, and two bowel movements a day in patients with portal systemic encephalopathy. In constipation In adults, the starting daily dose should be 20 g, taken as a single dose with the morning or evening meal. After a few days, a daily dose of 10 g may be enough. In children, the mean dose is 0.25 g/kg body weight daily. For 1 to 6 years it is 2.5 to 5 gm, for 6 to 12 years it is 5 to 10 gm, and for 12 to 16 years it is 10 to 20 gm. The effect of lactitol mostly appears within a few hours of taking it. In some cases, though, the first laxative response may be delayed until the second or third day of use. So patients should be advised to keep up an adequate daily fluid intake. In portal systemic encephalopathy The dose should be adjusted to the severity of the patient's disease and how they respond. The recommended starting dose is 0.5 to 0.7 gm/kg body weight daily, divided into three doses taken with meals.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.