Informational only — Not medical advice. Always consult a licensed healthcare provider.

Community data Updated 23 hours ago

Indications

L-Ornithine L-Aspartate is used to treat Hepatic Encephalopathy, Acute Liver Failure, and Hyperammonemia due to Acute and Chronic Hepatitis. It is also given in Fatty Liver, Alcoholic Liver damage, Liver Cirrhosis and Post hepatitis convalescence, and as an adjunct to hepatotoxic drugs, among other liver conditions of this kind.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

L-Ornithine L-Aspartate is a stable combination of two natural amino acids that the body already makes, L-Ornithine and L-Aspartate. Once it's taken, it breaks down quickly into these two parts.

L-Ornithine is a substrate of the urea cycle. It turns toxic ammonia into non-toxic urea, and the kidneys then remove the urea. This helps a diseased liver carry out its normal work smoothly (detoxification). The process brings down a raised level of ammonia in the blood (hyperammonemia), which is a common problem in most liver diseases.

L-Aspartate is an essential part of the citric acid cycle, which releases energy (ATP). Because of this, it also helps damaged liver cells to regenerate.

Pregnancy & Breastfeeding

L-Ornithine L-Aspartate should be avoided during pregnancy and while breastfeeding.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Sachet: Dissolve 1 to 2 sachets of granules in a large amount of fluid (for example, a glass of water or juice) and take it by mouth 3 times a day, during or after meals. Injection (Infusion Concentrate): The recommended dose is up to 20 gm (4 ampoules daily). If the patient is in pre-coma (loss of consciousness) or coma (clouding of consciousness), up to 8 ampoules can be given within 24 hours, depending on how severe the condition is. Administration: L-Ornithine L-Aspartate infusion concentrate can be added to any of the usual intravenous fluids, such as 0.9% Sodium Chloride, 5% Dextrose and Ringer's lactate. The normal dilution rate is 1 ampoule per 100 ml of I.V. fluid. A dose should not go above 6 ampoules per 500 ml infusion. The solution mixtures were stable up to 24 hours. Infusion rate: 5 gm/h at maximum.