Jogaraj Guggulu

Jogaraj-guggulu is a proper preparation of different herbs, and it is therapeutically effective in rheumatoid disorder. The phytochemical constituents in these herbs possibly help give the desired therapeutic effect in ailments as a whole. A literature survey shows that guggulsterone E & Z from Commiphora mukul and piperine from Piper longum are responsible for the anti-inflammatory activity. Gallic acid from Terminalia chebula & Terminalia belerica and ascorbic acid from Emblica officinalis are responsible for the antioxidant activity.

Commiphora mukul

Guggulu is an exudate, obtained as an oleogum resin from the stem of Commiphora mukul. It has analgesic and anti-inflammatory properties because of the guggulsterone E & Z in it. Guggulsterone shows its anti-inflammatory effect by inhibiting the activation of nuclear factor-kappa-B (NF-kappa-B).

Plumbago zeylanicum

Plumbago zeylanicum contains flavonoids, which are known to inhibit prostaglandin synthesis. These flavonoids help reduce pain perception by suppressing pain substances like prostaglandins & bradykinin. The plant also controls excessive collagenase production. One study found that its analgesic effect is comparable to that of Indomethacin.

Nigela sativa

Nigella sativa contains thymoquinone, which inhibits the effect of the nociceptive system or inflammatory mediators and so reduces pain. The anti-nociceptive effect of Nigella sativa is comparable with that of Naproxen.

Vanda Roxburghii

Vanda Roxburghii reduces pain and inflammation. Heptacosane & octacosan from Vanda roxburghii show anti-inflammatory activity.

Zingiber officinale

Gingerol from Zingiber officinale has anti-inflammatory and analgesic properties. This formulation inhibits the production of prostaglandins & leukotrienes, which are responsible for pain and inflammation.

Rock salt is used in the short term to help these plants perform. This herb acts as a carrier material.