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Community data Updated 2 months ago

Ivermectin

Anthelmintic Prescription
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Indications

Scabies

Riovera tablet is indicated for the treatment of Strongyloidiasis, Onchocerciasis, Filariasis, and Scabies & Head lice. Strongyloidiasis of the intestinal tract: Riovera is indicated for the treatment of intestinal (i.e., nondisseminated) strongyloidiasis due to the nematode parasite Strongyloides stercoralis. This indication is based on clinical studies of both comparative and open-label designs, in which 64-100% of infected patients were cured following a single 200-mcg/kg dose of Riovera. Onchocerciasis: Riovera is indicated for the treatment of onchocerciasis due to the nematode parasite Onchocerca volvulus. This indication is based on randomized, double-blind, placebo-controlled and comparative studies conducted in 1427 patients in onchocerciasis-endemic areas of West Africa. The comparative studies used diethylcarbamazine citrate (DEC-C).

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Ivermectin acts by binding closely and strongly to glutamate-gated chloride ion channels. These channels are found in the nerve and muscle cells of invertebrates. Once ivermectin attaches to them, the cell membrane lets chloride ions pass through much more easily. The nerve or muscle cell then becomes hyperpolarized, and the parasite eventually dies.

Pregnancy & Breastfeeding

Pregnancy Category C. Ivermectin does not appear to be selectively toxic to the developing fetus, but there are no adequate, well-controlled studies in pregnant women. For this reason, it should not be used during pregnancy, as safety in pregnancy has not been established.

Nursing mothers: Ivermectin passes into breast milk in low concentrations. Treatment of nursing mothers should be considered only when the risk to the mother of delaying treatment outweighs the possible risk to the newborn.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: For treatment (if COVIO positive), the dose of Ivermectin is 2 tablets of 6 mg once daily for 5 days (2+0+0 for 5 days). For prophylaxis, a single dose is taken on Day 1 and the same dose is repeated on Day 7. The dose depends on body weight: Body weight 15-24 kg: 1 tablet of Ivermectin 3 mg Body weight 25-35 kg: 1 tablet of Ivermectin 6 mg Body weight 36-50 kg: 1 tablet of Ivermectin 6 mg + 1 tablet of Ivermectin 3 mg Body weight 51-65 kg: 2 tablets of Ivermectin 6 mg Body weight 66-79 kg: 2 tablets of Ivermectin 6 mg + 1 tablet of Ivermectin 3 mg Body weight >80 kg: 3 tablets of Ivermectin 6 mg Strongyloidiasis The recommended dose of Ivermectin for strongyloidiasis is a single oral dose meant to provide approximately 200 mcg/kg of body weight. Patients should take the tablets on an empty stomach with water. In general, extra doses aren't needed. Follow-up stool examinations should still be done to confirm that the infection has been cleared. Dosage guidelines for Ivermectin in strongyloidiasis: Body weight (kg) 15-24: dose 3 mg/kg Body weight (kg) 25-35: dose 6 mg/kg Body weight (kg) 36-50: dose 9 mg/kg Body weight (kg) 51-65: dose 12 mg/kg Body weight (kg) 66-79: dose 15 mg/kg Body weight (kg) >80: dose 200 mcg/kg Onchocerciasis The recommended dose of Ivermectin is a single oral dose meant to provide approximately 150 mcg of Ivermectin per kg of body weight, taken on an empty stomach with water. The most commonly used dose interval is 12 months. For individual patients, retreatment may be considered at intervals as short as 3 months. Dosage guidelines for Ivermectin in onchocerciasis: Body weight (kg) 15-25: dose 3 mg/kg Body weight (kg) 26-44: dose 6 mg/kg Body weight (kg) 45-64: dose 9 mg/kg Body weight (kg) 65-84: dose 12 mg/kg Body weight (kg) >85: dose 150 mcg/kg

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.