Indications
Isosorbide Dinitrate + Hydralazine Hydrochloride tablet is used to treat heart failure, alongside standard therapy, in patients who identify themselves as black. It helps them live longer, delays the time to hospital admission for heart failure, and improves their own reports of how well they can function in daily life. Limitations of use: there is little experience with this medicine in patients with NYHA class IV heart failure.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
The way isosorbide dinitrate and hydralazine hydrochloride work together to benefit people with heart failure has not been established. Isosorbide dinitrate is a vasodilator, and it acts on both arteries and veins. It releases nitric oxide, which activates guanylyl cyclase, and this finally relaxes the smooth muscle of the blood vessels.
Several well-controlled clinical trials used exercise testing to assess how well nitrates given over a long period work against angina. In the large majority of these trials, the active agents were no more effective than placebo after 24 hours (or less) of continuous therapy. Researchers tried to overcome this nitrate tolerance by raising the dose, even to levels far above those used for short-term treatment, but these attempts have consistently failed. The response to nitrates returns only after they have been absent from the body for several hours.
Hydralazine hydrochloride is a selective dilator of arterial smooth muscle. Animal data suggests that hydralazine may also lessen tolerance to nitrates.
Pregnancy & Breastfeeding
Pregnancy
There are no data on the use of isosorbide dinitrate with hydralazine hydrochloride in pregnant women. The data on its individual components are also too limited to judge whether first trimester use carries a risk of major birth defects or miscarriage. For hydralazine, the published data on use in the second and third trimesters have not shown any link with adverse pregnancy outcomes.
Lactation
Think about the benefits of breastfeeding for the child's development and health, and set them against the mother's clinical need for this combination. Also consider any possible adverse effects on the breastfed child, whether they come from this combination or from the mother's underlying condition.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.
Side Effects & Interactions
Side Effects
No side-effect data recorded yet.