Informational only — Not medical advice. Always consult a licensed healthcare provider.

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Indications

Visican injection is a radiographic contrast agent used for the following purposes. For intra-arterial procedures, in adults and pediatric patients 12 years of age and over, it is used for intra-arterial digital subtraction angiography (270 and 320 mg Iodine/mL), as well as angiocardiography (left ventriculography and selective coronary arteriography), peripheral arteriography, visceral arteriography, and cerebral arteriography (320 mg Iodine/mL). In pediatric patients less than 12 years of age, it is used for angiocardiography, cerebral arteriography, and visceral arteriography (320 mg Iodine/mL). For intravenous procedures, in adults and pediatric patients 12 years of age and over, it is used for computed tomography (CT) imaging of the head and body and excretory urography (270 and 320 mg Iodine/mL), CT imaging peripheral venography (270 mg Iodine/mL), and coronary computed tomography angiography (CCTA) to assist diagnostic evaluation of patients with suspected coronary artery disease (320 mg Iodine/mL). In pediatric patients less than 12 years of age, it is used for CT imaging of the head and body and excretory urography (270 mg Iodine/mL).

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Iodixanol is injected into a blood vessel, and it opacifies the vessels in the path of flow of the contrast agent. This lets the internal structures be seen on x-ray until the agent is significantly diluted and eliminated. In imaging of the body, iodinated contrast agents diffuse from the vascular into the extravascular space. In a normal brain with an intact blood-brain barrier, contrast does not diffuse into the extravascular space. In patients with a disrupted blood-brain barrier, the contrast agent accumulates in the interstitial space in the region of disruption.

Iodixanol is a dimeric, isosmolar, nonionic, water soluble, iodinated x-ray contrast agent for intravascular administration.

Pharmacokinetics

Distribution: In an in vitro human plasma study, iodixanol did not bind to protein. The volume of distribution was 0.26 liter per kg of body weight, which is consistent with distribution to the extracellular space.

Metabolism: Iodixanol metabolites have not been demonstrated.

Excretion: Plasma and urine levels suggest that the body clears iodixanol mainly through the kidneys. In adults, about 97% of the injected dose is excreted unchanged in urine within 24 hours, and less than 2% is excreted in feces within five days after injection.

Pharmacodynamics

As with other iodinated contrast agents, after Visican Injection is given, the degree of enhancement is directly related to the iodine content of the dose. Peak iodine plasma levels occur immediately after a rapid intravascular injection. They then fall quickly, within 5 to 10 minutes, and this is accounted for by dilution in the vascular and extravascular fluid compartments.

Pregnancy & Breastfeeding

Pregnancy: No data are available on the use of Iodixanol during pregnancy, so any risks it may pose cannot be assessed. Breastfeeding: A mother who is breastfeeding may express and discard her breast milk for 10 hours after receiving Iodixanol.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Adult Dosage: For intra-arterial use, at a concentration of 270/320 mg I/ml, arteriographies are given as 5 to 10 ml per injection, selective cerebral arteriography as 40 to 60 ml per injection, and peripheral aortography as 30 to 60 ml per injection. For angiocardiography, at a concentration of 320 mg I/ml, the left ventricle and aortic root are given 30 to 60 ml per injection, and selective coronary arteriography is given 4 to 8 ml per injection. For intravenous use, at a concentration of 270/320 mg I/ml, urography CT enhancement uses 40 to 80 ml, CT of the body uses 50 to 150 ml, and CT of the head uses 75 to 150 ml. Paediatric Dosage: For intra-arterial use, at a concentration of 320 mg I/ml, cardioangiography is given as 1 to 2 ml/kg, with a maximum recommended dose of 10 ml/kg; all doses depend on age, weight and pathology. For intravenous use, at a concentration of 270/320 mg I/ml, urography in children under 7 kg and in children over 7 kg is given as 2 to 3 ml/kg up to 50 ml, though up to 150 ml may be given in a few cases. CT enhancement, at a concentration of 270/320 mg I/ml, for CT of the body is given as 2 to 3 ml/kg up to 50 ml, though up to 150 ml may be given in a few cases. For upper gastrointestinal studies in children, at a concentration of 320 mg I/ml, the dosage must be adjusted individually to allow optimal visualization, generally around 5 ml/kg body weight, with doses of 10 to 240 ml having been studied.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.