Informational only — Not medical advice. Always consult a licensed healthcare provider.

Community data Updated 23 hours ago

Indications

Intravenous fat emulsion gives calories and essential fatty acids to patients who need parenteral nutrition for a long time, usually for more than 5 days. It is also a source of essential fatty acids when a deficiency occurs. It forms part of the intravenous diet in all parenteral nutrition indications. Omegaven is described in the same way. It is a source of calories and essential fatty acids for patients who need parenteral nutrition for extended periods (usually more than 5 days), and a source of essential fatty acids when a deficiency occurs. It is part of the intravenous diet in all parenteral nutrition indications, including: Preoperative and postoperative nutritional disturbances where an improved nitrogen balance is required. Nutritional disorders or disturbances of nitrogen balance caused by inadequate or failing intestinal absorption. The causes include tumours in the gastrointestinal tract and acute or chronic intestinal diseases (peritonitis, ulcerative colitis, terminal ileitis). Burns, to reduce the frequently excessive nitrogen losses. Prolonged unconsciousness, for example after cranial trauma or poisoning, where enteral feeding is inappropriate or impossible. Impaired renal function, where a concentrated source of energy may be indicated to reduce protein breakdown. Cachexia. Patients with essential fatty acid deficiency who cannot maintain or restore a normal essential fatty acid pattern by oral intake.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Intravenous fat emulsion is a 10% preparation of refined soyabean oil, meant to be given as an intravenous nutrient. It prevents Essential Fatty Acid Deficiency (EFAD) and corrects the clinical signs of EFAD. Patients who need complete parenteral nutrition, however, also need complementary vitamin supplements.

These emulsions are made from either soyabean or safflower oil and supply a mixture of neutral triglycerides, mostly unsaturated fatty acids. The main fatty acids are linoleic, oleic and palmitic acids. The emulsion also contains 1.2% egg yolk phospholipids as an emulsifier, and glycerol to adjust tonicity. IV fat emulsions are isotonic, so they may be given by the central or the peripheral venous route.

Intravenous fat emulsion is formulated as a concentrated source of energy, to be used together with carbohydrates and amino acids in parenteral nutrition. It is isotonic, and it provides a source of basal phosphate requirements and a source of vitamin E.

Pregnancy & Breastfeeding

Nobody has shown that intravenous fat emulsion is completely safe for the foetus or for a breastfed infant. So it should be given with caution during pregnancy and while a woman is breastfeeding.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Total parenteral nutrition: intravenous fat emulsion is given as part of TPN, through a peripheral vein or by a central venous catheter. Fat emulsion should make up no more than 60% of the patient's total caloric intake, and carbohydrates and amino acids should supply the remaining 40% or more. Adult: Start the infusion at 1 ml/min for the first 15 to 30 mins. If no adverse reactions occur, the rate can be raised to 2 ml/min. Give only 500 ml on the first day and increase the dose the following day. The daily dose must not go above 2.5 g/kg. Children: Start at 0.1 ml/min for the first 10 to 15 mins. If no adverse reactions occur, the rate can be raised to 1 g/kg in 4 hours. The daily dose must not go above 3 g/kg. Infants: Start at 0.5 g/kg/24 hours. The dose may be increased according to the infant's ability to eliminate fat. The maximum recommended dose is 3 g/kg/24 hours. Fatty acid deficiency: To correct EFAD, 8% to 10% of the caloric intake should be supplied as intravenous fat emulsion, which gives an adequate amount of linoleic acid. Throw away whatever is left in an opened bottle, and don't save it for later use. Don't use any bottle where the emulsion looks separated.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.