Indications
Intravenous fat emulsion gives calories and essential fatty acids to patients who need parenteral nutrition for a long time, usually for more than 5 days. It is also a source of essential fatty acids when a deficiency occurs. It forms part of the intravenous diet in all parenteral nutrition indications. Omegaven is described in the same way. It is a source of calories and essential fatty acids for patients who need parenteral nutrition for extended periods (usually more than 5 days), and a source of essential fatty acids when a deficiency occurs. It is part of the intravenous diet in all parenteral nutrition indications, including: Preoperative and postoperative nutritional disturbances where an improved nitrogen balance is required. Nutritional disorders or disturbances of nitrogen balance caused by inadequate or failing intestinal absorption. The causes include tumours in the gastrointestinal tract and acute or chronic intestinal diseases (peritonitis, ulcerative colitis, terminal ileitis). Burns, to reduce the frequently excessive nitrogen losses. Prolonged unconsciousness, for example after cranial trauma or poisoning, where enteral feeding is inappropriate or impossible. Impaired renal function, where a concentrated source of energy may be indicated to reduce protein breakdown. Cachexia. Patients with essential fatty acid deficiency who cannot maintain or restore a normal essential fatty acid pattern by oral intake.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Intravenous fat emulsion is a 10% preparation of refined soyabean oil, meant to be given as an intravenous nutrient. It prevents Essential Fatty Acid Deficiency (EFAD) and corrects the clinical signs of EFAD. Patients who need complete parenteral nutrition, however, also need complementary vitamin supplements.
These emulsions are made from either soyabean or safflower oil and supply a mixture of neutral triglycerides, mostly unsaturated fatty acids. The main fatty acids are linoleic, oleic and palmitic acids. The emulsion also contains 1.2% egg yolk phospholipids as an emulsifier, and glycerol to adjust tonicity. IV fat emulsions are isotonic, so they may be given by the central or the peripheral venous route.
Intravenous fat emulsion is formulated as a concentrated source of energy, to be used together with carbohydrates and amino acids in parenteral nutrition. It is isotonic, and it provides a source of basal phosphate requirements and a source of vitamin E.
Pregnancy & Breastfeeding
Nobody has shown that intravenous fat emulsion is completely safe for the foetus or for a breastfed infant. So it should be given with caution during pregnancy and while a woman is breastfeeding.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.
Side Effects & Interactions
Side Effects
No side-effect data recorded yet.