Insulin Glulisine

Adults: Individualize and adjust the dosage of insulin glulisine according to the route of administration, the person's metabolic needs, blood glucose monitoring results and the glycemic control goal. The dosage may also need changing when switching from another insulin, when physical activity changes, when other medicines are added or changed, when meal patterns change, when kidney or liver function changes, or during an acute illness. Subcutaneous Injection: Inject within 15 minutes before a meal or within 20 minutes after starting a meal, into the abdomen, thigh or upper arm. Rotate injection sites within the same region to reduce the risk of lipodystrophy and localized cutaneous amyloidosis. Insulin glulisine should generally be used in regimens with an intermediate or long-acting insulin. Continuous Subcutaneous Infusion (Insulin Pump): Give it by continuous subcutaneous infusion using an insulin pump, in a region recommended in the pump manufacturer's instructions. Rotate infusion sites within the same region to reduce the risk of lipodystrophy and localized cutaneous amyloidosis. Do not dilute or mix insulins in external insulin pumps. Intravenous Administration: Give it only under medical supervision, after diluting to a concentration of 0.05 to 1 unit/mL insulin glulisine in 0.9% sodium chloride injection, USP, using polyvinyl chloride infusion bags.