Indications
Insulin Degludec + Insulin Aspart Premixed combines insulin degludec, a long-acting human insulin analog, with insulin aspart, a rapid-acting human insulin analog. It is used to improve glycemic control in patients with diabetes mellitus who are 1 year of age and older.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Insulin degludec and insulin aspart bind specifically to the human insulin receptor, and they produce the same pharmacological effects as human insulin. Insulin lowers blood glucose because, once it binds to receptors on muscle and fat cells, those cells take up glucose more easily. At the same time, it stops the liver from releasing glucose.
Pregnancy & Breastfeeding
Insulin Degludec + Insulin Aspart Premixed is Pregnancy Category C. Animal reproduction studies have shown an adverse effect on the fetus, and there are no adequate and well-controlled studies in humans. Even so, the potential benefits may warrant use of the medicine in pregnant women despite the potential risks.
There are no data on whether insulin degludec is present in human milk, what effect it has on a breastfed infant, or what effect it has on milk production. Insulin degludec is present in rat milk. One small published study reported that exogenous insulin, including insulin aspart, was present in human milk. But there is not enough information to say what effects insulin aspart has on the breastfed infant, and no information is available on its effects on milk production.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.