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Human Menopausal Gonadotrophin

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Indications

Human Menopausal Gonadotrophin is used for sterility in women who have hypo- or normogonadotropic ovarian insufficiency, where it stimulates follicle growth. It is also used for sterility in men who have hypo- or normogonadotropic hypogonadism. In men it is given in combination with HCG to stimulate spermatogenesis.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Human Menopausal Gonadotrophin acts directly on the ovaries and the testes, and it has both a gametotropic and a steroidogenic effect. In the ovaries, the FSH component increases the number of growing follicles and stimulates their development. FSH also raises the production of estradiol in the granulosa cells by aromatizing androgens that come from the theca cells under the influence of the LH component. In the testes, FSH brings about the change from premature to mature Sertoli cells. Mainly, it causes the seminal canals to mature and the spermatozoa to develop. However, a high concentration of androgens inside the testes is necessary for this, and it can be reached by treating with HCG beforehand.

The medicine is not effective when taken by mouth, so it is injected i.m. or s.c. Its biological effect comes mainly from its FSH and LH content. The pharmacokinetics after i.m. or s.c. injection were tested product specifically. The maximum serum level of FSH is reached 6 to 48 hours after an i.m. injection and 6 to 36 hours after an s.c. injection, respectively. After that, the serum level falls with a half-life of 56 hours (i.m.) and 51 hours (s.c.), respectively. Human Menopausal Gonadotrophin is passed out mainly through the kidneys.

Pregnancy & Breastfeeding

Human Menopausal Gonadotrophin has no indication for use during pregnancy or while a woman is breastfeeding.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Sterility in females The dose of Human Menopausal Gonadotrophin for inducing follicle growth in normo- or hypogonadotropic women differs from one woman to another. It depends on how the ovaries react, so the response should be checked with ultrasound examinations of the ovaries and by measuring estradiol levels. If the dose is too high for the woman being treated, multiple uni- and bilateral follicle growth can occur. The medicine is given intramuscularly or subcutaneously. In general, treatment starts with a daily dose equal to 75 to 150 IU FSH. If the ovaries don't respond, the dose can be raised slowly until a rise in estradiol secretion and follicle growth is clear. The same dose is then continued until the pre-ovulatory estradiol serum level is reached. If the level rises too quickly, the dose should be reduced. To induce ovulation, 5000 or 10000 IU HCG is injected i.m. 1 to 2 days after the last dose of Human Menopausal Gonadotrophin. Note: If a dose too high for the woman has been given, the HCG that follows can cause unintentional hyperstimulation of the ovaries. Sterility in males Treatment begins with 2 X 5000 IU HCG a week, until a normal testosterone serum level is reached. After that, an additional weekly dose of Human Menopausal Gonadotrophin (3 X 75 to 150 IU FSH + 75 to 150 IU LH) is given for a few months.