Informational only — Not medical advice. Always consult a licensed healthcare provider.

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Human Chorionic Gonadotrophin

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Indications

Human Chorionic Gonadotrophin is used in women to induce ovulation when infertility is caused by anovulation or by impaired follicle-ripening. It is also used to prepare the follicles for puncture in controlled ovarian hyperstimulation programs (ART), and for luteal phase support. Another use is in threatened and habitual abortion. In men, Human Chorionic Gonadotrophin is used for hypogonadotropic hypogonadism (some cases of idiopathic dysspermias have also shown a positive response to gonadotropins). It is used for delayed puberty linked to insufficient gonadotropic pituitary function, and for cryptorchidism that is not due to anatomical obstruction. It is also used to treat oligospermia.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Highly Purified Human Chorionic Gonadotrophin has LH activity. LH is needed for the normal growth and maturation of female and male gametes, and for the production of gonadal steroids.

In women, Human Chorionic Gonadotrophin is given in place of the natural mid-cycle LH surge. It brings on the final phase of follicular maturation, which leads to ovulation. It is also given in place of natural LH during the luteal phase.

In men, Human Chorionic Gonadotrophin is given to stimulate the Leydig cells so that they produce testosterone.

Pharmacokinetic properties: after a single injection, plasma levels of Human Chorionic Gonadotrophin reach their maximum at about six hours. Around 80 percent of the dose is metabolized, mainly in the kidneys. After an intramuscular (IM) injection, the apparent elimination half-life is about 2 days. With the recommended dose regimens and this half-life, the medicine does not accumulate.

Pregnancy & Breastfeeding

Human Chorionic Gonadotrophin is Pregnancy Category X. Studies in animals or in human beings have shown foetal abnormalities, or there is evidence of foetal risk from human experience, or both. The risk of using the drug in pregnant women clearly outweighs any possible benefit, so it is contraindicated in women who are or may become pregnant.

Use in lactation: it must not be used during lactation.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: After the solvent is added to the freeze-dried substance, the reconstituted Human Menopausal Gonadotrophin solution should be given slowly by intramuscular injection. In women, for ovulation induction and preparation of follicles for puncture, one injection of 5000 to 10000 IU Human Menopausal Gonadotrophin is usually given to complete treatment with an FSH-containing preparation. For luteal phase support, two repeat injections of 2500 to 5000 IU are given. Each may be given within nine days following ovulation or embryo transfer (for example on day 3, 6 and 9 after ovulation induction). For threatened and habitual abortion, 5000 IU is given as a deep intramuscular injection twice weekly from the time of diagnosis (all before the 7th week of gestation). In men with hypogonadotropic hypogonadism, the dose is 2500 to 5000 IU Human Menopausal Gonadotrophin, two times per week. If the main complaint is sterility, additional FSH-containing doses (50 IU FSH) are to be given, either daily or two to three times a week. This treatment should continue for at least three months before any improvement in spermatogenesis can be expected. Testosterone replacement therapy should be suspended during this treatment. Once the improvement is achieved, Human Menopausal Gonadotrophin alone may in some cases maintain it.