Informational only — Not medical advice. Always consult a licensed healthcare provider.

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Community data Updated 23 hours ago

Hepatitis B Immuneglobulin

Vaccines Prescription
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Indications

Hepatitis B Immuneglobulin is used to stop hepatitis B virus infection from coming back after a liver transplant, when the liver failure was caused by that virus. It also gives antibodies against the virus quickly, so hepatitis B can be prevented in these cases. The first is accidental exposure in non-immunised people, meaning people who have not been vaccinated against the hepatitis B virus, including those whose vaccination is incomplete or whose status is unknown. The second is haemodialysed patients, that is patients with severe renal failure who need their blood cleaned by an artificial kidney, and here the medicine is used until vaccination has become effective. The third is the newborn of a mother who carries the hepatitis B virus. The last is people who showed no immune response after vaccination (the vaccination did not become effective) and who need continuous protection because they stay at risk of catching the virus.

⚠️ Always consult a registered physician before taking any medicine.

Pregnancy & Breastfeeding

Pregnancy: The safety of Hepatitis B Immuneglobulin in human pregnancy has not been established in controlled clinical trials, so it should only be given with caution to pregnant women and breast-feeding mothers. Still, clinical experience with immunoglobulins suggests that no harmful effects are expected on the course of pregnancy, on the fetus or on the neonate.

Breastfeeding: Immunoglobulins pass into the milk and may help transfer protective antibodies to the neonate.

Fertility: Clinical experience with immunoglobulins suggests that no harmful effects on fertility are expected.

Driving and using machines: No effects on the ability to drive and use machines have been observed.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Hepatitis B Immuneglobulin is used to prevent hepatitis B virus infection from coming back after a liver transplant for liver failure caused by the virus. In adults, the suggested dose is 2000 IU IM every 15 days after the transplant, leaving out the first week. For long-term treatment, the dose should be adjusted so the serum level of HBsAg antibodies stays above 100 IU/l in HBV-DNA negative patients and above 500 IU/l in HBV-DNA positive patients. Adequate virostatic agents should also be considered where appropriate, as a standard part of preventing hepatitis B reinfection. In children, UMAN BIG has no relevant use for preventing the virus from coming back after liver transplantation for hepatitis B induced liver failure. For preventing hepatitis B in other situations, the doses depend on who is being protected. After accidental exposure in people who are not immunised, give at least 500 IU (International Units), depending on how intense the exposure was. Give it as soon as possible after exposure, preferably within 24 to 72 hours. For haemodialysed patients, the dose is 8 to 12 IU/kg with a maximum of 500 IU, given every 2 months until the vaccination has become effective. For a newborn whose mother carries the hepatitis B virus, give 30 to 100 IU/kg at birth or as soon as possible after birth. The immunoglobulin may need to be repeated until the vaccination has become effective. In all of these situations, vaccination against hepatitis B virus is highly recommended. The first vaccine dose can be given on the same day as the human hepatitis B immunoglobulin, but at a different injection site. If a person has not shown an immune response after vaccination (no measurable hepatitis B antibodies) and continuous prevention is still necessary, the doctor may consider giving 500 IU to adults and 8 IU/kg to children every 2 months.