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Halobetasol Propionate + Tazarotene

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Indications

Psoriasis

Halobetasol Propionate + Tazarotene lotion is used to treat plaque psoriasis in adults.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Corticosteroids take part in cell signalling, immune function, inflammation and protein regulation. In plaque psoriasis, though, the exact way halobetasol propionate works is not known.

Tazarotene is a retinoid prodrug. The body converts it to its active form, tazarotenic acid (the carboxylic acid of tazarotene), by deesterification. Tazarotenic acid binds to all three members of the retinoic acid receptor (RAR) family, RARα, RARβ and RARγ, but it is relatively selective for RARβ and RARγ. It may modify gene expression. What these findings mean clinically for treating plaque psoriasis is not known.

Pregnancy & Breastfeeding

This lotion, which contains Halobetasol Propionate and Tazarotene, must not be used by women who are pregnant. No data exist on whether Tazarotene, Halobetasol Propionate or its metabolites pass into human milk.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Apply a thin layer of Halobetasol Propionate + Tazarotene lotion once a day, covering only the affected areas, and rub it in gently. If you have a bath or shower before applying, make sure the skin is dry first. The total amount used should not go above about 50 gm per week, because the medicine can suppress the hypothalamic-pituitary-adrenal (HPA) axis. Don't use the lotion in the mouth, in the eyes or in the vagina. Use in children and adolescents: the safety and effectiveness of Halobetasol Propionate + Tazarotene lotion in patients under 18 years of age have not been evaluated.