Glucosamine Sulfate + Chondroitin

Glucosamine is a natural amino-sugar. The body produces it, and it is also found in certain foods. It is the most fundamental building block the body needs to make glycosaminoglycans (GAGs) such as Hyaluronic Acid, Keratan Sulfate and Chondroitin Sulfate. GAGs bind with protein and form proteoglycans, which are the essential building block of articular cartilage. When cartilage in a joint deteriorates, Osteoarthritis develops. Glucosamine also helps form ligaments, tendon, nails and various other connective tissues. When we take an artificially synthesized Glucosamine Sulfate supplement, the Glucosamine level in the body goes up, and this helps production and repair of cartilage. Glucosamine also activates chondrocytes in the cartilage, and these help produce GAGs and proteoglycans. Chondroitin Sulfate is a glycosaminoglycan (acid muco polysaccharide) found in connective tissue, especially in the articular cartilage of all mammals. A Chondroitin Sulfate supplement acts much like Glucosamine Sulfate, because it too provides substrate for proteoglycans. Chondroitin also protects existing healthy cartilage from premature decline by preventing the MMP (Matrix metalloproteinase) enzyme, which breaks down the proteoglycans. Combining Glucosamine with Chondroitin Sulfate shows a synergistic effect. Data supports that this combination is very much effective in severe cases of Osteoarthritis, where it treats both the signs and symptoms and modifies disease progression. It prevents Osteoarthritis in normal adults. In Osteoarthritic pain it is as effective as NSAIDs, with significantly better tolerability and clinical compliance. It is also helpful during the repair phase of musculo-skeletal soft tissue injuries such as tendon or ligament strains.